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指導教員紹介

青柳秀紀 教授

論文・受賞等
Fujita, T., Ogbonna, J., Tanaka, H., Aoyagi, H.: Effect of reactive oxygen species on α-tocopherol production in mitochondria and chloroplast of Euglena gracilis. J. Appl. Phycol. 21, 185-191 (2009).

Mitsumoto, K., Yabusaki, K., Aoyagi, H.: Classification of pollen species using autofluorescence image analysis. J. Biosci. Bioeng., 107, 90-94 (2009).

青柳秀紀, 榎戸仁美, 薮崎克己:フラーレンナノ粒子と花粉の付着特性の解析. 日本花粉学会誌, 54, 103-106 (2008).

榎戸仁美, Charles U. UGWU, 光本浩太郎, 薮崎克己, 青柳秀紀: 産地が異なるスギおよびヒノキ花粉の自家蛍光特性と粒径の比較解析. 日本花粉学会誌, 54, 69-77, (2008).

Watanabe, K., Imase, M., Aoyagi, H., Ohmura, N., Saiki, H., Tanaka, H.: Development of a novel artificial medium based on utilization of algal photosynthetic metabolites by symbiotic heterotrophs. Journal of Applied Microbiology, 105, 741-751 (2008).

Ugwu, C., Tokiwa, Y., Aoyagi, H., Tanaka, H.: Ultraviolet light mutagenesis and production of (R)-3-hydroxybutyric acid monomer using Cupriavidus necator. J. Appl. Microbiol., 105, 236-242 (2008).

Semba, H., Ichige, E., Imanaka, T., Atomi, H., Aoyagi, H.: Development of a system for overproduction of active form hydroxynitrile lyase. Appl. Microbiol. Biotechnol., 79, 563-569 (2008).

Ugwu, C., Aoyagi, H.: Influence of shading an inclined tubular photobioreactor surfaces on algal biomass productivity of C. sorokiniana. Photosynthetica, 46, 283-285 (2008).

Fujita, T., Aoyagi, H., Ogbonna, J., Tanaka, H.: Effect of mixed organic substrate on α-tocopherol production by Euglena gracilis in photoheterotrophic culture. Appl. Microbiol. Biotechnol., 79, 371-378 (2008).

Imase, M., Watanabe, K., Aoyagi, H., Tanaka, H.: Construction of artificial symbiotic community using Chlorella-symbiont association as a model. FEMS Microbiol. Ecol., 63, 273-282 (2008).

Aoyagi, H., Ishii, H., Ugwu, C., Tanaka, H.: Effect of heat generated products from uronic acids on the physiological activities of microbial cells and it's application. Biores. Technol. 99, 4534-4538 (2008).

Hideno, A., Aoyagi, H., Ogbonna, J., Tanaka, H.: Optimization of thermal drying by thermal analysis for enhancement of enzymatic hydrolysis of spent-sawdust matrix after cultivation of Grifola frondosa. Energy and Fuels, 22, 120-122 (2008).

Hayashi, A., Aoyagi, H., Kinjo, K., Yoshimura, T., Tanaka, H.: Development of an efficient method for screening microorganisms by using symbiotic association between insect (Nasutitermes takasagoensis Shiraki) and intestinal microorganisms. Appl. Microbiol. Biotechnol., 75, 1437-1446 (2007).

Miyata, R., Noda, N., Tamaki, H., Kinjyo, K., Aoyagi, H., Uchiyama, H., Tanaka, H.: Influence of feed components on the symbiotic bacterial community structure in the gut of wood-feeding higher termite Nasutitermes takasagoensis. Biosci. Biotech. Biochem., 71, 1244-1251 (2007).

Aoyagi, H.: Development of a quantitative method for the determination of the optimal conditions for protoplast isolated from cultured plant cells. Biotechnology Letters, 28, 1687-1694 (2006).

Iwase, A., Aoyagi, H., Ohme-Takagi, M., Tanaka, H.: Development of novel system for producing ajmalicine and serpentine using direct culture of leaves in Catharanthus roseus intact plant. J. Biosci. Bioeng., 99, 208-215 (2005).

(平成18年度日本生物工学会論文賞受賞)
Mera, N., Aoyagi, H., Nakasono, S., Iwasaki, K., Saiki, H., Tanaka, H.: Analysis of gene expression in yeast protoplasts using DNA microarray and their application for efficient production of invertase andα-glucosidase. J. Biosci. Bioeng., 97, 169-183 (2004).

(平成17年度日本生物工学会論文賞受賞)
Fett-Neto, A.G.; Hideki, Aoyagi, Hideo Tanaka H, and Frank DiCosmo, F.: Antitumor agents: taxol and taxanes - production by yew cell culture. In: R. A. Meyers (editor), Encyclopedia of Molecular Cell Biology and Molecular Medicine, Vol. 1Wiley-VCH,Weinheim, 415-438. (2004)

Nobuaki Mera, Hideki Aoyagi, Satoshi Nakasono, Kazuhiro Iwasaki, Hiroshi Saiki and Hideo Tanaka: Analysis of gene expression in yeast protoplasts using DNA microarray and their application for efficient production of invertase and α-glucosidase. Journal of Bioscience and Bioengineering, 97, 169-183 (2004).

Nobuaki Mera, Hideki Aoyagi Frank DiCosmo and Hideo Tanaka: Production of cell wall accumulative enzymes using immobilized protoplasts of Catharanthus roseus in agarose gel. Biotechnology Letters, 25, 1687-1693 (2003).

Hideki Aoyagi and Hideo Tanaka: Efficient production of useful metabolites using protoplasts. 37th international symposium of Korean Society of Life Science. Cultivation and it’s application of bioindustry. p. 18-25 (2002).

Hideki Aoyagi, Frank DiCosmo and Hideo Tanaka: Efficient paclitaxel production using protoplasts isolated from cultured cells of Taxus cuspidata. Planta Medica, 68, 420-424 (2002).

Hideki Aoyagi, Jin Yasuhira, Atsushi Kuno, Kimihiro Ono, Chiharu Akimoto, Shigeki Yoshida and Hideo Tanaka: Distribution of alginate oligomers in Catharanthus roseus and Wasabia japonica cells cultured in a medium containing alginate oligomers. Biotechnology Letters, 24, 1125-1129 (2002).

Chiharu Akimoto-Tomiyama, Hideki Aoyagi, Tetsuo Ozawa and Hideo Tanaka: Production of 5’-phosphodiesterase by Catharanthus roseus cells promoted by heat- degradated products generated from uronic acid. Journal of Bioscience and Bioengineering, 94, 154-159 (2002).

Hideki Aoyagi, Yasuko Kobayashi, Kumiko Yamada, Mineyuki Yokoyama, Ken Kusakari and Hideo Tanaka: Efficient production of saikosaponins in Bupleurum falcatum root fragments combined with signal transducers. Applied Microbiology and Biotechnology, 57, 482-488 (2001).

(平成12年度日本生物工学会照井賞受賞)
青柳秀紀:人工細胞壁を装着したプロトプラストによる有用物質の高速度生産システム. 生物工学会誌, 79, 105-112, (2001).

Hideo Tanaka, Takuji Kamogawa, Hideki Aoyagi, Isao Kato and Ryoichi Nakajima: Invertase production by Saccharomyces cerevisiae protoplasts immobilized in strontium alginate gel beads. Journal of Bioscience and Bioengineering, 89, 498-500 (2000).

Chiharu Akimoto, Hideki Aoyagi, Frank DiCosmo and Hideo Tanaka: Synergistic effect of active oxygen species and alginate on chitinase production by Wasabia japonica cells and its application. Journal of Bioscience and Bioengineering, 89, 131-137 (2000).

田中秀夫 名誉教授

論文・受賞等
Nobuaki Mera, Hideki Aoyagi, Satoshi Nakasono, Kazuhiro Iwasaki, Hiroshi Saiki and Hideo Tanaka: Analysis of gene expression in yeast protoplasts using DNA microarray and their application for efficient production of invertase and α-glucosidase. Journal of Bioscience and Bioengineering, 97, 169-183 (2004).

Fett-Neto, A.G.; Hideki, Aoyagi, Hideo Tanaka H, and Frank DiCosmo, F.: Antitumor agents: taxol and taxanes - production by yew cell culture. In: R. A. Meyers (editor), Encyclopedia of Molecular Cell Biology and Molecular Medicine, Vol. 1Wiley-VCH,Weinheim, 415-438. (2004)

Robel, N.D., Ogbonna, J.C., and Tanaka, H.: A novel circulating loop bioreactor with cells immobilized in loofa (Luffa cylindrica) sponge for the bioconversion of raw cassava starch to ethanol. Appl. Microbiol. Biotechnol., 60, 671-678 (2003).

Ugwu, C.U., Ogbonna, J.C., and Tanaka, H.: Design of static mixers for inclined tubular photobioreactors. J. Appl. Phycol., 15, 217-223 (2003).

Robel, N.D., Ogbonna, J.C., and Tanaka, H.: L-lactic acid production from raw cassava starch in a circulating loop bioreactor with cells immobilized in loofa (Luffa cylindrical) sponge. Biotechnol. Lett., 25, 1093-1098 (2003).

Mera, N., Aoyagi, H., DiCosmo, F., and Tanaka, H.: Production of cell wall accumulative enzymes using immobilized protoplasts of Catharanthus roseus in agarose gel. Biotechnol. Lett., 25, 1687-1693 (2003).

Ugwu, C.U., Ogbonna, J.C., and Tanaka, H.: Improvement of mass transfer characteristics and productivities of inclined tubular photobioreactors by installation of internal static mixers. Appl. Microbiol. Biotechnol., 58, 600-607 (2002).

Ogbonna, J.C., Ichige, E., and Tanaka, H.: Interaction between photoautotrophic and heterotrophic metabolism in photoheterotrophic cultures of Euglena gracilis. Appl. Microbiol. Biotechnol., 58, 532-538 (2002).

Ogbonna, J.C., Ichige, E., and Tanaka, H.: Regulating the ratio of photoautotrophic to heterotrophic metabolic activities in photoheterotrophic culture of Euglena gracilis and its application to a-tocopherol production. Biotechnol. Lett., 24, 953-958 (2002).

Aoyagi, H., Yasuhira, J., Kuno, A., Ono, K., Akimoto, C., Yoshida, S., and Tanaka, H.: Distribution of alginate oligomers in Catharanthus roseus and Wasabia japonica cells cultured in a medium containing alginate oligomers. Biotechnol. Lett., 24, 1125-1129 (2002).

Aoyagi, H., DiCosmo, F., .and Tanaka, H.: Efficient paclitaxel production using the protoplasts isolated from cultured cells of Taxus cuspidata. Planta Med., 68, 420-424 (2002). H. Tanaka : Technological problems in cultivation of plant cells at high density. Biotechnology and Bioengineering 67, 775-790 (2000).

Biotechnology and Bioengineering 40周年記念号国際優秀論文賞受賞

J.C. Ogbonna, H.Yoshizawa, and H. Tanaka :Treatment of high strength organic wastewater by a mixed culture of photosynthetic microorganisms. J. Appl. Phycol., 12, 277-284 (2000).

S. Okino, K. Iwasaki, O. Yagi, and H. Tanaka : Removal of mercuric chloride by immobilized cells of genetically modified Pseudomonas putida PpY101/pSR134. J. Environ. Biotechnol. 1, 41-47 (2001)

J.C. Ogbonna, T. Soejima, C.U. Ugwu, and H. Tanaka : An integrated system of solar light, artificial light and organic carbon supply for cyclic photoautotrophic heterotrophic cultivation of photosynthetic cells under day-night cycles. Biotechnology Lett., 23, 1401-1406 (2001).

H. Tanaka, T. Kamogawa, H. Aoyagi, I. Kato, and R. Nakajima : Invertase production by Saccharomyces cerevisiae protoplasts immobilized in strontium alginate gel beads. J. Biosci. Bioeng., 89, 498-500 (2000).


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