◇ Kato K, Udagawa R, Hayashi Y, Maki M, Yanagida M, Higashiura S, Yagishita R, Shimamoto H,
and Kimura K.
SF3B14 is involved in the centrosome regulation through splicing of TUBGCP6 pre-mRNA.
Biochem. Biophys. Res. Commun. (2022) 588:133-139.

◇ Fujimura A, Hayashi Y, Kato K, Kogure Y, Kameyama M, Shimamoto H, Daitoku H, Fukamizu A, Hirota T, and Kimura K.
Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B.
Nucleic Acids Res. (2020) 48:6583-6596.

◇ Lu W, Kim J, Tabara S, Kwon C, Mizukami H, Kimura K, and Fukamizu A.
The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation.
Biochem. Biophys. Res. Commun. (2019) 514:1185-1191.

◇ Hayashi Y, Fujimura A, Kato K, Udagawa R, Hirota T, and Kimura K.
Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry.
Sci. Adv. (2018) 4:eaap7777.

◇ Ohkuro M, Kim J, Kuboi Y, Hayashi Y, Mizukami H, Kobayashi-Kuramochi H, Muramoto K, Shirato M, Michikawa-Tanaka F, Moriya J, Kozaki T, Takase K, Chiba K, Agarwala L K, Kimura T, Kotake M, Kawahara T, Yoneda N, Hirota S, Azuma H, Ozasa-Komura N, Ohashi Y, Muratani M, Kimura K, Hishinuma I,
and Fukamizu A.
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease.
Nat. commun. (2018) 9:1982.

現在の研究に関連する論文を載せています。

◇ Hayashi Y, Kato K, and Kimura K.
The hierarchical structure of the perichromosomal layer comprises Ki67, ribosomal RNAs, and nucleolar proteins.
Biochem. Biophys. Res. Commun. (2017) 493:1043-1049.

◇ Kumazawa T, Nishimura K, Katagiri N, Hashimoto S, Hayashi Y, and Kimura K.
Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A.
Sci. Rep. (2015) 5:10854.

◇ Katagiri N, Kuroda T, Kishimoto H, Hayashi Y, Kumazawa T, and Kimura K.
The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription.
Sci. Rep. (2015) 5:8903.

◇ Nishimura K, Kumazawa T, Kuroda T, Katagiri N, Tsuchiya M, Goto N, Furumai R, Murayama A, Yanagisawa J, and Kimura K.
Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation.
Cell Rep. (2015) 10:1310-1323.

◇ Hayashi Y, Kuroda T, Kishimoto H, Wang C, Iwama A, and Kimura K.
Downregulation of rRNA transcription triggers cell differentiation.
PLoS One. (2014) 9:e98586.

◇ Ono W, Hayashi Y, Yokoyama W, Kuroda T, Kishimoto H, Ito I, Kimura K, Akaogi K, Waku T, and Yanagisawa J.
The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.
J. Biol. Chem. (2014) 289:4928-4940.

◇ Ono W, Akaogi K, Waku T, Kuroda T, Yokoyama W, Hayashi Y, Kimura K, Kishimoto H, and Yanagisawa J.
Nucleolar protein, Myb-binding protein 1A, specifically binds to nonacetylated p53 and efficiently promotes transcriptional activation.
Biochem. Biophys. Res. Commun. (2013) 434:659-663.

◇ Fujimura A, Kishimoto H, Yanagisawa J, and Kimura K.
Enhancer of rudimentary homolog (ERH) plays an essential role in the progression of mitosis by promoting mitotic chromosome alignment.
Biochem. Biophys. Res. Commun. (2012) 423:588-492.

◇ Kumazawa T, Nishimura K, Kuroda T, Ono W, Yamaguchi C, Katagiri N, Tsuchiya M, Masumoto H, Nakajima Y, Murayama A, Kimura K, and Yanagisawa J.
Novel nucleolar pathway connecting intracellular energy status with p53 activation.
J. Biol. Chem. (2011) 286:20861-20869.

◇ Tsuchiya M, Katagiri N, Kuroda T, Kishimoto H, Nishimura K, Kumazawa T, Iwasaki N, Kimura K, and Yanagisawa J.
Critical role of the nucleolus in activation of the p53-dependent postmitotic checkpoint.
Biochem. Biophys. Res. Commun. (2011) 407:378-382.

◇ Kuroda T, Murayama A, Katagiri N, Ohta YM, Fujita E, Masumoto H, Ema M, Takahashi S, Kimura K, and Yanagisawa J.
RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
EMBO J. (2011) 30:1054-1066.

◇ Takemoto A, Maeshima K, Ikehara T, Yamaguchi K, Murayama A, Imamura S, Imamoto N, Yokoyama S, Hirano T, Watanabe Y, Hanaoka F, Yanagisawa J, and Kimura K.
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
Nat. Struct. Mol. Biol. (2009) 16:1302-1308.

◇ Takemoto A, Murayama A, Katano M, Urano T, Furukawa K, Yokoyama S, Yanagisawa J, Hamaoka F, and Kimura K.
Analysis of the role of Aurora B on the chromosomal targeting of condensin I.
Nucleic Acids Res. (2007) 35:2403-2412

◇ Lee CP, Chen JY, Wang JT, Kimura K, Takemoto A, Lu CC, and Chen MR.
EBV BGLF4 Kinase Induces Premature Chromosome Condensation through Activation of Condensin and Topoisomerase II.
J. Virol. (2007) 81:5166-5180

◇ Tsuyama T, Inou K, Seki M, Seki T, Kumata Y, Kobayashi T, Kimura K, Hanaoka F, Enomoto T, and Tada S.
Chromatin loading of Smc5/6 is induced by DNA replication but not by DNA double-strand breaks.
Biochem. Biophys. Res. Commun. (2006) 351:935-939.

◇ Takemoto A, Kimura K, Yanagisawa J, YokoyamaS, and Hanaoka F.
Negative regulation of condensin I by CK2-mediated phosphorylation.
EMBO J. (2006) 25:5339-5348.

◇ Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, Taniguchi H, Furukawa K, and Urano T.
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.
J. Biol. Chem. (2004) 279:47201-47211.

◇ Takemoto A, Kimura K, Yokoyama S, and Hanaoka F.
Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin.
J. Biol. Chem. (2004) 279:4551-4559.

◇ Bazett-Jones DP, Kimura K, and Hirano T.
Efficient supercoiling of DNA by a single condensin complex as revealed by electron spectroscopic imaging.
Mol. Cell (2002) 9:1183-1190.

◇ Kimura K, Cuvier O, and Hirano T.
Chromosome condensation by a human condensin complex in Xenopus egg extracts.
J. Biol. Chem. (2001) 276:5417-5420.

◇ Kimura K and Hirano T.
Dual roles of the 11S regulatory subcomplex in condensin functions.
Proc. Natl. Acad. Sci. USA. (2000) 97:11972-11977.

◇ Kimura K, Rybenkov VV, Crisona NJ, Hirano T, and Cozzarelli NR.
13S condensin actively reconfigures DNA by introducing global positive writhe: implications for chromosome condensation.
Cell (1999) 98:239-248.

◇ Kimura K, Hirano M, Kobayashi R, and Hirano T.
Phosphorylation and activation of 13S condensin by cdc2 in vitro.
Science (1998) 282:487-490.

◇ Kimura K and Hirano T.
ATP-dependent positive supercoiling of DNA by 13S condensin: A biochemical implication for chromosome condensation.
Cell (1997) 90:625-634.

◇ Kimura K, Nozaki N, Enomoto T, Tanaka M, and Kikuchi A.
Analysis of M phase-specific phosphorylation of DNA topoisomerase II.
J. Biol. Chem. (1996) 271:21439-21445.

◇ Kimura K, Saijo M, Tanaka M, and Enomoto T.
Phosphorylation-independent stimulation of DNA topoisomerase II alpha activity.
J. Biol. Chem. (1996) 271:10990-10995.

◇ Kimura K, Nozaki N, Saijo M, Kikuchi A, Ui M, and Enomoto T.
Identification of the nature of modification that causes the shift of DNA topoisomerase II beta to apparent higher molecular weight forms in the M phase.
J. Biol. Chem. (1994) 269:24523-24526.

◇ Kimura K, Saijo M, Ui M, and Enomoto T.
Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase.
J. Biol. Chem. (1994) 269, 1173-1176.